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Literature summary for 2.7.1.91 extracted from

  • Sobue, S.; Murakami, M.; Banno, Y.; Ito, H.; Kimura, A.; Gao, S.; Furuhata, A.; Takagi, A.; Kojima, T.; Suzuki, M.; Nozawa, Y.; Murate, T.
    v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins (2008), Oncogene, 27, 6023-6033.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
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Mus musculus
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Expression

Organism Comment Expression
Mus musculus inhibition of protein kinase C-alpha, signal transducers and activators of transcription 3 and c-Jun NH2-terminal kinase inhibition suppresses SPHK1 expression in v-Src-transformed NIH-3T3 cells, whereas their overexpression increases SPHK1 mRNA. Modulation of AUF1 and HuR by their overexpression or siRNA reveals that SPHK1 mRNA in v-Src- and mock-NIH3T3 is regulated reciprocally by these factors down
Mus musculus v-Src-transfected cells show both increased SPHK1 mRNA and enzyme activity. Inhibition of protein kinase C-alpha, signal transducers and activators of transcription 3 and c-Jun NH2-terminal kinase inhibition suppresses SPHK1 expression in v-Src-transformed NIH-3T3 cells, whereas their overexpression increases SPHK1 mRNA. Modulation of AUF1 and HuR by their overexpression or siRNA reveals that SPHK1 mRNA in v-Src- and mock-NIH3T3 is regulated reciprocally by these factors up

General Information

General Information Comment Organism
physiological function siRNA of SPHK1 inhibits cell proliferation of v-Src-transformed NIH-3T3 cells Mus musculus