Literature summary for 2.7.1.91 extracted from

Anelli, V.; Gault, C.; Cheng, A.; Obeid, L.
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells: Role of hypoxia-inducible factors 1 and 2 (2008), J. Biol. Chem., 283, 3365-3375.

Search for more literature for 2.7.1.91

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
U-373MG cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	hypoxia increases SK1 mRNA levels, protein expression, and enzyme activity, followed by intracellular sphingosine 1-phosphate production and sphingosine 1-phosphate release. Knockdown of hypoxia-inducible factor HIF-2 by small interfering RNA abolishes the induction of SK1 and the production of extracellular shpingosine 1-phosphate after CoCl2 treatment, whereas HIF-1 small interfering RNA results in an increase of HIF-2 and of SK1 protein levels. HIF-2 binds the SK1 promoter	up

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)