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Literature summary for 2.7.1.91 extracted from

  • Sobue, S.; Nemoto, S.; Murakami, M.; Ito, H.; Kimura, A.; Gao, S.; Furuhata, A.; Takagi, A.; Kojima, T.; Nakamura, M.; Ito, Y.; Suzuki, M.; Banno, Y.; Nozawa, Y.; Murate, T.
    Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells (2008), Int. J. Hematol., 87, 266-275.
    View publication on PubMed
Search for more literature for 2.7.1.91

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
BALL-1 cell
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 Homo sapiens
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CMK-86 cell
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 Homo sapiens
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HEL cell
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 Homo sapiens
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HL-60 cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
KOPT-K1 cell
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 Homo sapiens
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KU-812 cell
-
 Homo sapiens
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leukemia cell
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 Homo sapiens
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leukemia cell line CMK-115 Homo sapiens
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NALL-1 cell
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 Homo sapiens
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NALM-17 cell
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 Homo sapiens
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NB-4 cell
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 Homo sapiens
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RPMI-8402 cell
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 Homo sapiens
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THP-6 cell
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 Homo sapiens
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U-937 cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function cell lines sensitive to daunorubicin show increased ceramide content, while cell lines resistant to daunorubicin do not when treated with low doses of drug. Upon daunorubicin treatment, sphinganine 1-phosphate decreases more in the sensitive cell lines than in the resistant cell lines. A sphinganine kinase inhibitor recovers the daunorubicin sensitivity of daunorubicin resistant cells. The modulation of isoform Sk1 gene expression by overexpression or using siRNA affects the daunorubicin sensitivity of cell lines Homo sapiens