Literature summary for 2.7.1.91 extracted from

Zebol, J.R.; Hewitt, N.M.; Moretti, P.A.; Lynn, H.E.; Lake, J.A.; Li, P.; Vadas, M.A.; Wattenberg, B.W.; Pitson, S.M.
The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1 (2009), Int. J. Biochem. Cell Biol., 41, 822-827.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Subunits

Subunits	Comment	Organism
More	isoform SK1 interacts with subunit 7 of cytosolic chaperonin CCT, i.e. chaperonin containing t-complex polypeptide, also called TRiC for TCP-1 ring complex, a hexadecameric chaperonin that binds unfolded polypeptides. Other CCT/TRiC subunits also associate with SK1 in HEK293T cell lysates in an ATP-sensitive manner. CCT/TRiC binds specifically to newly translated SK1. Depletion of functional CCT/TRiC through the use of RNA interference in HeLa cells or temperature sensitive CCT mutants reduces cellular SK1 activity	Homo sapiens

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Release 2023.1 (January 2023)