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BRENDA support

Literature summary for 2.7.1.91 extracted from

  • Snider, A.J.; Kawamori, T.; Bradshaw, S.G.; Orr, K.A.; Gilkeson, G.S.; Hannun, Y.A.; Obeid, L.M.
    A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis (2009), FASEB J., 23, 143-152.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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General Information

General Information Comment Organism
physiological function SK1-/- mice treated with dextran sulfate sodium have significantly less blood loss, weight loss, colon shortening, colon histological damage, and splenomegaly than wild-type mice. SK1-/- mice have no systemic inflammatory response, and wild-type but not SK1-/- mice treated with dextran sulfate sodium have significant increases in blood sphingosine 1-phosphate levels, colon SK1 message and activity, and colon neutrophilic infiltrate. Unlike wild-type mice, SK1-/- mice fail to show colonic COX-2 induction despite an exaggerated TNF-alpha response Mus musculus