Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-threo-dihydrosphingosine | treatment of Jurkat and U-937 cells induces apoptosis and produces dramatic increases in SphK1 expression, the latter being a result of apoptotic stress | Homo sapiens | |
N,N-dimethylsphingosine | inhibition of both isoforms Sphk1 and Sphk2. Treatment of Jurkat and U-937 cells results ina large increase in expression of SphK1 concomitant with induction of apoptosis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | treatment with inhibitors N,N-dimethylsphingosine or DL-threo-dihydrosphingosine or with doxorubicin leads to increase in expression as a result of apoptotic stress. The caspase inhibitor ZVAD reduces not only doxorubicin-induced lethality but also the increased expression of SphK1 and secretion of sphingosine 1-phosphate | up |