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Literature summary for 2.7.1.91 extracted from

  • Gude, D.R.; Alvarez, S.E.; Paugh, S.W.; Mitra, P.; Yu, J.; Griffiths, R.; Barbour, S.E.; Milstien, S.; Spiegel, S.
    Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal (2008), FASEB J., 22, 2629-2638.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
DL-threo-dihydrosphingosine treatment of Jurkat and U-937 cells induces apoptosis and produces dramatic increases in SphK1 expression, the latter being a result of apoptotic stress Homo sapiens
N,N-dimethylsphingosine inhibition of both isoforms Sphk1 and Sphk2. Treatment of Jurkat and U-937 cells results ina large increase in expression of SphK1 concomitant with induction of apoptosis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
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Homo sapiens
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THP-1 cell
-
Homo sapiens
-
U-937 cell
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Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens treatment with inhibitors N,N-dimethylsphingosine or DL-threo-dihydrosphingosine or with doxorubicin leads to increase in expression as a result of apoptotic stress. The caspase inhibitor ZVAD reduces not only doxorubicin-induced lethality but also the increased expression of SphK1 and secretion of sphingosine 1-phosphate up