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Literature summary for 2.7.1.91 extracted from

  • Kusner, D.J.; Thompson, C.R.; Melrose, N.A.; Pitson, S.M.; Obeid, L.M.; Iyer, S.S.
    The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages (2007), J. Biol. Chem., 282, 23147-23162.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
jasplakinolide causes a 85% increase in SK activity Homo sapiens
jasplakinolide causes a 85% increase in SK activity Mus musculus
latrunculin B causes a 38% increase in SK activity Homo sapiens
latrunculin B causes a 38% increase in SK activity Mus musculus

Protein Variants

Protein Variants Comment Organism
G82D catalytically inactive mutant Homo sapiens
G82D catalytically inactive mutant Mus musculus
S225A the mutation prevents ERK1/2-mediated phosphorylation and membrane localization of SK1 Homo sapiens
S225A the mutation prevents ERK1/2-mediated phosphorylation and membrane localization of SK1 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
erythro-dihydrosphingosine 0.025 mM, dose-dependent inhibition Homo sapiens
erythro-dihydrosphingosine 0.025 mM, dose-dependent inhibition Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Mus musculus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
lesser amounts of immunoreactive protein migrate in the 45-48 kDa range Homo sapiens
additional information
-
lesser amounts of immunoreactive protein migrate in the 45-48 kDa range Mus musculus
43000
-
SDS-PAGE Homo sapiens
43000
-
SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYA1
-
-
Mus musculus Q8CI15
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-
macrophage
-
Mus musculus
-
RAW-264.7 cell
-
Mus musculus
-
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
?
ATP + sphingosine
-
Mus musculus ADP + sphingosine 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
SK1
-
Homo sapiens
SK1
-
Mus musculus
sphinganine kinase
-
Homo sapiens
sphinganine kinase
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Mus musculus