Activating Compound | Comment | Organism | Structure |
---|---|---|---|
jasplakinolide | causes a 85% increase in SK activity | Homo sapiens | |
jasplakinolide | causes a 85% increase in SK activity | Mus musculus | |
latrunculin B | causes a 38% increase in SK activity | Homo sapiens | |
latrunculin B | causes a 38% increase in SK activity | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G82D | catalytically inactive mutant | Homo sapiens |
G82D | catalytically inactive mutant | Mus musculus |
S225A | the mutation prevents ERK1/2-mediated phosphorylation and membrane localization of SK1 | Homo sapiens |
S225A | the mutation prevents ERK1/2-mediated phosphorylation and membrane localization of SK1 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
erythro-dihydrosphingosine | 0.025 mM, dose-dependent inhibition | Homo sapiens | |
erythro-dihydrosphingosine | 0.025 mM, dose-dependent inhibition | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Mus musculus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
lesser amounts of immunoreactive protein migrate in the 45-48 kDa range | Homo sapiens |
additional information | - |
lesser amounts of immunoreactive protein migrate in the 45-48 kDa range | Mus musculus |
43000 | - |
SDS-PAGE | Homo sapiens |
43000 | - |
SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NYA1 | - |
- |
Mus musculus | Q8CI15 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Homo sapiens | - |
macrophage | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
THP-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SK1 | - |
Homo sapiens |
SK1 | - |
Mus musculus |
sphinganine kinase | - |
Homo sapiens |
sphinganine kinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Mus musculus |