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Literature summary for 2.7.1.91 extracted from

  • Cuvillier, O.
    Sphingosine kinase-1 - a potential therapeutic target in cancer (2007), Anticancer Drugs, 18, 105-110.
    View publication on PubMed

Application

Application Comment Organism
medicine potential therapeutic target in anti-cancer therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole
-
Homo sapiens
B5354c
-
Homo sapiens
camptothecin
-
Homo sapiens
dimethylsphingosine potent competitive inhibitor Homo sapiens
DL-threo-dihydrosphingosine potent competitive inhibitor Homo sapiens
docetaxel
-
Homo sapiens
F-12509A
-
Homo sapiens
S-12183a
-
Homo sapiens
S-12183b
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYA1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
breast
-
Homo sapiens
-
breast cancer cell
-
Homo sapiens
-
cervical carcinoma cell
-
Homo sapiens
-
colon
-
Homo sapiens
-
colonic cancer cell
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
gastric cancer cell
-
Homo sapiens
-
hepatoma cell
-
Homo sapiens
-
kidney
-
Homo sapiens
-
leukemia cell
-
Homo sapiens
-
lung
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
melanoma cell
-
Homo sapiens
-
neuroblastoma cell
-
Homo sapiens
-
ovary
-
Homo sapiens
-
pancreatic cancer cell
-
Homo sapiens
-
prostate adenocarcinoma cell
-
Homo sapiens
-
rectum
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
stomach
-
Homo sapiens
-
uterus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
ir

Synonyms

Synonyms Comment Organism
sphingosine kinase-1
-
Homo sapiens
SPHK1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0037
-
B5354c
-
Homo sapiens
0.004
-
F-12509A
-
Homo sapiens
0.005
-
dimethylsphingosine
-
Homo sapiens
0.01
-
DL-threo-dihydrosphingosine
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
-
Homo sapiens 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole
0.0016
-
-
Homo sapiens S-12183b
0.0025
-
-
Homo sapiens S-12183a