Application | Comment | Organism |
---|---|---|
medicine | potential therapeutic target in anti-cancer therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole | - |
Homo sapiens | |
B5354c | - |
Homo sapiens | |
camptothecin | - |
Homo sapiens | |
dimethylsphingosine | potent competitive inhibitor | Homo sapiens | |
DL-threo-dihydrosphingosine | potent competitive inhibitor | Homo sapiens | |
docetaxel | - |
Homo sapiens | |
F-12509A | - |
Homo sapiens | |
S-12183a | - |
Homo sapiens | |
S-12183b | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NYA1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
breast | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
cervical carcinoma cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
gastric cancer cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
leukemia cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
neuroblastoma cell | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
prostate adenocarcinoma cell | - |
Homo sapiens | - |
rectum | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
uterus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
sphingosine kinase-1 | - |
Homo sapiens |
SPHK1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0037 | - |
B5354c | - |
Homo sapiens | |
0.004 | - |
F-12509A | - |
Homo sapiens | |
0.005 | - |
dimethylsphingosine | - |
Homo sapiens | |
0.01 | - |
DL-threo-dihydrosphingosine | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
- |
Homo sapiens | 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole | |
0.0016 | - |
- |
Homo sapiens | S-12183b | |
0.0025 | - |
- |
Homo sapiens | S-12183a |