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Literature summary for 2.7.1.91 extracted from

  • Leiber, D.; Banno, Y.; Tanfin, Z.
    Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms (2007), Am. J. Physiol., 292, C240-C250.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
endothelin-1 1 nM, 2.4fold and 2.7fold increase of activity after 5 and 10 min, respectively Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
dimethylsphingosine 0.01 mM Rattus norvegicus
DL-threo-dihydrosphingosine 0.002 mM Rattus norvegicus
additional information not inhibited by 0.25% Triton X-100 Rattus norvegicus
Ro-31-8220
-
Rattus norvegicus
U-73122
-
Rattus norvegicus
Y-27632
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q91V26
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myometrium
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
Rattus norvegicus ADP + sphingosine 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
sphinganine kinase
-
Rattus norvegicus
SPHK1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus Ro-31-8220
0.00055
-
at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus U-73122
0.0021
-
at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus Y-27632
0.0024
-
at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus DL-threo-dihydrosphingosine
0.0024
-
at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus dimethylsphingosine