Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.91 extracted from

  • Min, J.; Traynor, D.; Stegner, A.L.; Zhang, L.; Hanigan, M.H.; Alexander, H.; Alexander, S.
    Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin (2005), Eukaryot. Cell, 4, 178-189.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.91

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of gene sgkA leads to increased resistance to the anticancer drug cisplatin and altered growth behaviour Dictyostelium discoideum

Protein Variants

Protein Variants Comment Organism
additional information disruption mutants of genes sgkA and sgkB, single mutants with reduced activity, or double mutants nearly inactive, show increased sensitivity to the anticancer drug cisplatin and altered growth behaviour Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Dictyostelium discoideum 5829
-
nucleus
-
 Dictyostelium discoideum 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + sphingosine Dictyostelium discoideum
-
 ADP + sphingosine 1-phosphate
-
 ?
additional information Dictyostelium discoideum sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
 isozymes SgkA and SgkB encoded by the genes sgkA and sgkB
-

Source Tissue

Source Tissue Comment Organism Textmining
pseudopodium
-
 Dictyostelium discoideum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity of mutant strains Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
 Dictyostelium discoideum ADP + sphingosine 1-phosphate
-
 ?
additional information sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin Dictyostelium discoideum ?
-
 ?

Synonyms

Synonyms Comment Organism
SGK
-
 Dictyostelium discoideum
sphinganine kinase
-
 Dictyostelium discoideum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
 assay at Dictyostelium discoideum

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Dictyostelium discoideum