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Literature summary for 2.7.1.81 extracted from

  • Veiga-da-Cunha, M.; Hadi, F.; Balligand, T.; Stroobant, V.; Van Schaftingen, E.
    Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine (2012), J. Biol. Chem., 287, 7246-7255.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.81

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
 GTP pH 7.1, 30°C Homo sapiens
0.0076
-
 5-hydroxy-L-lysine cosubstrate GTP, pH 7.1, 30°C Homo sapiens
0.28
-
 5-hydroxy-L-lysine cosubstrate ATP, pH 7.1, 30°C Homo sapiens
0.81
-
 ATP pH 7.1, 30°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens A2RU49
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-hydroxy-L-lysine catalytic efficiency is 22fold higher with GTP than with ATP Homo sapiens ADP + O-phosphohydroxy-L-lysine
-
 ?
GTP + 5-hydroxy-D-lysine best substrate is the physiological form 5-hydroxy-L-lysine but human enzyme can also phosphorylate at a lower rate at least one other isomer Homo sapiens GDP + O-phosphohydroxy-D-lysine
-
 ?
GTP + 5-hydroxy-L-lysine best substrate is the physiological form 5-hydroxy-L-lysine but human enzyme can also phosphorylate at a lower rate at least one other isomer Homo sapiens GDP + O-phosphohydroxy-L-lysine
-
 ?
additional information no substrates for phosphorylation: ethanolamine, hydroxyproline, homoserine, serine, or choline Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AGPHD1
-
 Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
5
-
 ATP pH 7.1, 30°C Homo sapiens
12
-
 5-hydroxy-L-lysine cosubstrate ATP, pH 7.1, 30°C Homo sapiens
45
-
 5-hydroxy-L-lysine cosubstrate GTP, pH 7.1, 30°C Homo sapiens
110
-
 GTP pH 7.1, 30°C Homo sapiens