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Literature summary for 2.7.1.78 extracted from

  • Mair, B.; Popow, J.; Mechtler, K.; Weitzer, S.; Martinez, J.
    Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components (2013), Biochem. Soc. Trans., 41, 831-837.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K127A inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5'-dephospho-DNA Homo sapiens
-
ADP + 5'-phospho-DNA
-
?
additional information Homo sapiens the enzyme plays a role in tRNA splicing. The ATP-binding and/or hydrolysis capacity of CLP1 is required to enhance pre-tRNA cleavage ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5'-dephospho-DNA
-
Homo sapiens ADP + 5'-phospho-DNA
-
?
additional information the enzyme plays a role in tRNA splicing. The ATP-binding and/or hydrolysis capacity of CLP1 is required to enhance pre-tRNA cleavage Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cleavage and polyadenylation factor I subunit
-
Homo sapiens
CLP1
-
Homo sapiens
HEAB originally termed Homo sapiens

General Information

General Information Comment Organism
malfunction the lack of CLP1 kinase activity leads to progressive motor neuron loss and accumulation of novel 5' leader-5' exon tRNA fragments Homo sapiens