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Literature summary for 2.7.1.72 extracted from
- Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate (1967), Biochim. Biophys. Acta, 148, 335-341.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dihydrostreptomycin | - |
Streptomyces bikiniensis |  |
| additional information | no inhibition by sulfhydryl reagents, formamidine disulfide, p-chloromercuribenzoate | Streptomyces bikiniensis | |
| streptomycin | - |
Streptomyces bikiniensis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Streptomyces bikiniensis | |
| Mn2+ | can replace Mg2+ in activation | Streptomyces bikiniensis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + streptomycin | Streptomyces bikiniensis | streptomycin is secreted | ADP + streptomycin 6-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces bikiniensis | - |
strain ATCC 11062 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Streptomyces bikiniensis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Streptomyces bikiniensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dihydrostreptomycin | - |
Streptomyces bikiniensis | ADP + dihydrostreptomycin 6-phosphate | - |
? | |
| ATP + streptomycin | - |
Streptomyces bikiniensis | ADP + streptomycin 6-phosphate | - |
? | |
| ATP + streptomycin | streptomycin is secreted | Streptomyces bikiniensis | ADP + streptomycin 6-phosphate | - |
? | |
| additional information | no activity with GTP, CTP, UTP | Streptomyces bikiniensis | ? | - |
? | |
| additional information | no activity with N-amidinostreptamine, N'-amidinostreptamine, N-amidinoinosamine, dTTP | Streptomyces bikiniensis | ? | - |
? | |
| streptidine + ATP | - |
Streptomyces bikiniensis | streptidine 6-phosphate + ADP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Streptomyces bikiniensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Streptomyces bikiniensis | |
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Release 2023.1 (January 2023)
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