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Literature summary for 2.7.1.68 extracted from

  • Noda, Y.; Niwa, S.; Homma, N.; Fukuda, H.; Imajo-Ohmi, S.; Hirokawa, N.
    Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKalpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches (2012), Proc. Natl. Acad. Sci. USA, 109, 1725-1730.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.68

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of PIPKalpha in N1E-115 neuroblastoma cells, co-expression of His6-tagged KIF2A and GST-tagged PIPKalpha in Escherichia coli, binding analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information knockdown of isozyme PIPKalpha in neurites Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
neurite co-localization of KIF2A and PIPKalpha at the tips of neurites Mus musculus
-
-
plasma membrane KIF2A and PIPKalpha bind near the plasma membrane Mus musculus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-phosphate 5-kinase alpha
-
 Mus musculus
PIPKalpha
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction overexpression of PIPKalpha inhibits axon elongation via KIF2A in N1E-115 neuroblastoma cells Mus musculus
additional information identification of the binding domain for His6-tagged KIF2A and GST-tagged PIPKalpha interaction, overview Mus musculus
physiological function isozyme phosphatidylinositol 4-phosphate 5-kinase alpha, PIPKalpha, regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches, unique PIPK-mediated KIF2A-dependent mechanism controlling microtubule dynamics in neuronal development, overview. Murine PIPKalpha as a negative regulator of neurite formation in N1E-115 neuroblastoma cells and early-stage hippocampal neurons Mus musculus