Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | at Golgi-endoplasmic reticulum contact points | Saccharomyces cerevisiae | 5783 | - |
Golgi apparatus | at Golgi-endoplasmic reticulum contact points | Saccharomyces cerevisiae | 5794 | - |
Golgi apparatus | principal PI4Ks of the Golgi apparatus are PI4KIIalpha and PI4KIIIbeta | Homo sapiens | 5794 | - |
membrane | - |
Homo sapiens | 16020 | - |
membrane | - |
Saccharomyces cerevisiae | 16020 | - |
nucleus | PI4KIIIbeta shuttles through the nucleus | Homo sapiens | 5634 | - |
nucleus | Pik1 shuttles through the nucleus. Nuclear accumulation of Pik1 is promoted by nutrient, e.g. glucose, deprivation, a condition that also results in the release of PI4K effectors from Golgi membranes and slowing of the rate of secretion | Saccharomyces cerevisiae | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol | Saccharomyces cerevisiae | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | yeast Pik1 is phosphorylated by a protein kinase, phosphorylation promotes dissociation of Pik1 from Golgi membranes and association with the 14-3-3 proteins Bmh1 and Bmh2 in the cytosol | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Saccharomyces cerevisiae | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-kinase | - |
Homo sapiens |
phosphatidylinositol 4-kinase | - |
Saccharomyces cerevisiae |
PI4K | - |
Homo sapiens |
PI4K | - |
Saccharomyces cerevisiae |
Pik1 | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
metabolism | regulation of the Golgi system and 1-phosphatidyl-1D-myo-inositol 4-phosphate levels involving the enzyme, overview | Homo sapiens |
metabolism | regulation of the Golgi system and 1-phosphatidyl-1D-myo-inositol 4-phosphate levels involving the enzyme, overview | Saccharomyces cerevisiae |
additional information | nuclear accumulation of Pik1 is promoted by nutrient, e.g. glucose, deprivation, a condition that also results in the release of PI4K effectors from Golgi membranes and slowing of the rate of secretion | Saccharomyces cerevisiae |
physiological function | phosphatidylinositol 4-kinases regulate vesicle mediate export from the Golgi apparatus via phosphatidylinositol 4-phosphate binding effector proteins that control vesicle budding reactions and regulate membrane dynamics. Function of phosphatidylinositol 4-phosphate at the Golgi Membrane biogenesis and lipid homeostasis | Homo sapiens |
physiological function | phosphatidylinositol 4-kinases regulate vesicle mediate export from the Golgi apparatus via phosphatidylinositol 4-phosphate binding effector proteins that control vesicle budding reactions and regulate membrane dynamics. Function of phosphatidylinositol 4-phosphate at the Golgi Membrane biogenesis and lipid homeostasis | Saccharomyces cerevisiae |