Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | PtdIns 4-kinase Pik1 | Saccharomyces cerevisiae | 5794 | - |
nucleus | PtdIns 4-kinase Pik1 | Saccharomyces cerevisiae | 5634 | - |
plasma membrane | PtdIns 4-kinase Stt4 | Saccharomyces cerevisiae | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
three PtdIns 4-kinases: Pik1, Stt4, and Lsb6 | - |
Saccharomyces cerevisiae TKYM107 | - |
three PtdIns 4-kinases: Pik1, Stt4, and Lsb6 | - |
Synonyms | Comment | Organism |
---|---|---|
Pik1 | - |
Saccharomyces cerevisiae |
PtdIns 4-kinase | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | mitophagy is defective in the absence of Pik1 activity, and Atg9 and Atg27 trafficking is defective in the pik1 mutant. Because Pik1 functions at the late Golgi, the defect in Atg93GFP localization to the phagophore assembly site reflects accumulation of this protein in the trans-Golgi network | Saccharomyces cerevisiae |
physiological function | PtdIns 4-kinase Pik1 is involved in Atg9 trafficking through the Golgi and is involved in both nonselective and selective types of autophagy, overview. The Golgi-localized Pik1 is essential for secretory vesicle exit from the trans-Golgi network. The plasma membrane-localized Stt4 is involved in the Slt2 MAP kinase cascade and is required for autophagy. Isozymes Pik1 and Stt4 are responsible for the synthesis of the majority of cellular PtdIns4P, while isozyme Lsb6 is not essential | Saccharomyces cerevisiae |