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Literature summary for 2.7.1.67 extracted from

  • Wang, K.; Yang, Z.; Liu, X.; Mao, K.; Nair, U.; Klionsky, D.J.
    Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking (2012), J. Biol. Chem., 287, 37964-37972.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus PtdIns 4-kinase Pik1 Saccharomyces cerevisiae 5794
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nucleus PtdIns 4-kinase Pik1 Saccharomyces cerevisiae 5634
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plasma membrane PtdIns 4-kinase Stt4 Saccharomyces cerevisiae 5886
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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three PtdIns 4-kinases: Pik1, Stt4, and Lsb6
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Saccharomyces cerevisiae TKYM107
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three PtdIns 4-kinases: Pik1, Stt4, and Lsb6
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Synonyms

Synonyms Comment Organism
Pik1
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Saccharomyces cerevisiae
PtdIns 4-kinase
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction mitophagy is defective in the absence of Pik1 activity, and Atg9 and Atg27 trafficking is defective in the pik1 mutant. Because Pik1 functions at the late Golgi, the defect in Atg9–3GFP localization to the phagophore assembly site reflects accumulation of this protein in the trans-Golgi network Saccharomyces cerevisiae
physiological function PtdIns 4-kinase Pik1 is involved in Atg9 trafficking through the Golgi and is involved in both nonselective and selective types of autophagy, overview. The Golgi-localized Pik1 is essential for secretory vesicle exit from the trans-Golgi network. The plasma membrane-localized Stt4 is involved in the Slt2 MAP kinase cascade and is required for autophagy. Isozymes Pik1 and Stt4 are responsible for the synthesis of the majority of cellular PtdIns4P, while isozyme Lsb6 is not essential Saccharomyces cerevisiae