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Literature summary for 2.7.1.67 extracted from
- Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesicles (1991), J. Biol. Chem., 266, 13278-13283.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | maximal activity at 0.2% w/v | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Rattus norvegicus | 5886 | - |
| transport vesicle | glucose-transporter | Rattus norvegicus | 30133 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | Rattus norvegicus | phosphatidylinositol 4-kinase is a component of glucose transporter-containing vesicles. It may play a role in defining the fusogenic properties necessary to mediate membrane movement between the glucose transporter vesicles, plasma membranes and micosomes | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | phosphatidylinositol 4-kinase is a component of glucose transporter-containing vesicles. It may play a role in defining the fusogenic properties necessary to mediate membrane movement between the glucose transporter vesicles, plasma membranes and micosomes | Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | 0.03 | adenosine | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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