Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.67 extracted from

  • Tuazon, P.T.; Traugh, J.A.
    Phosphatidylinositol kinases from rabbit reticulocytes (1987), Methods Enzymol., 141, 210-222.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Mg2+ above 20 mM PI kinase I and II are inhibited. PI kinase III is only slightly inhibited at 50 mM Oryctolagus cuniculus
NaCl above 0.1 mM Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Oryctolagus cuniculus
0.1
-
ATP PI kinase I Oryctolagus cuniculus
0.1 0.15 ATP PI kinase III Oryctolagus cuniculus
0.2
-
ATP PI kinase II Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ the three enzyme forms are completely dependent on Mg2+, optimal activity at 4-10 mM Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
PI kinase I, II and III Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
Oryctolagus cuniculus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7.5 PI kinase III Oryctolagus cuniculus
7.5 9 PI kinase I Oryctolagus cuniculus
9
-
PI kinase II Oryctolagus cuniculus

pH Range

pH Minimum pH Maximum Comment Organism
6 8.5 pH 7.5: about 75% of maximal activity, pH 10.5: about 40% of maximal activity, PI kinase III Oryctolagus cuniculus
7.5 10.5 pH 7.5: about 50% of maximal activity, pH 10.5: about 65% of maximal activity, PI kinase I Oryctolagus cuniculus