Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | inhibits reaction with ATP | Mycobacterium tuberculosis | |
AMP | inhibits reaction with polyphosphate and glucose or ATP and glucose | Mycobacterium tuberculosis | |
ATP | at high concentrations competitive substrate inhibition with respect to glucose, ATP-dependent reaction | Mycobacterium tuberculosis | |
D-fructose 6-phosphate | inhibits reaction with polyphosphate and glucose or ATP and glucose | Mycobacterium tuberculosis | |
D-glucose 6-phosphate | inhibits reaction with polyphosphate and glucose | Mycobacterium tuberculosis | |
D-xylose | inhibits reaction with ATP; inhibits reaction with polyphosphate and glucose or ATP and glucose | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
D-glucose | pH 7.5, reaction with ATP | Mycobacterium tuberculosis | |
0.22 | - |
D-glucose | pH 8.6, reaction with ATP | Mycobacterium tuberculosis | |
0.88 | - |
ATP | pH 7.5 | Mycobacterium tuberculosis | |
1.4 | - |
ATP | pH 8.6 | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(phosphate)n + D-glucose = (phosphate)n-1 + D-glucose 6-phosphate | in the polyphosphate-dependent reaction the enzyme follows an ordered bi bi sequential mechanism with polyphosphate binding to the enzyme first and glucose 6-phosphate dissociating last. The ATP-dependent glucokinase reaction is consistent with an ordered bi bi sequential mechanism, with ATP binding to the enzyme first and glucose 6-phosphate leaving last | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(phosphate)n + D-glucose | polyphosphate is utilized nonprocessively with a preference for longer chains | Mycobacterium tuberculosis | (phosphate)n-1 + D-glucose 6-phosphate | - |
? | |
ATP + D-glucose | - |
Mycobacterium tuberculosis | ADP + D-glucose 6-phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
108 | - |
ATP | pH 7.5 | Mycobacterium tuberculosis | |
108 | - |
glucose | pH 7.5 | Mycobacterium tuberculosis | |
116 | - |
ATP | pH 8.6 | Mycobacterium tuberculosis | |
116 | - |
glucose | pH 8.6 | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
6.6 | - |
ATP | pH 7.5 | Mycobacterium tuberculosis | |
7.4 | - |
ATP | pH 8.6 | Mycobacterium tuberculosis |