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Literature summary for 2.7.1.56 extracted from
- Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1 (2013), Biochem. Biophys. Res. Commun., 440, 737-742.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Mus musculus | - |
| fibroblast | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| muscle | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PFK1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | nucleoredoxin, a thioredoxin-related oxidoreductase, is a interacting partner of PFK1. NRX binds directly to PFK1, and endogenous NRX and PFK1 interact in vivo. In NRX-/- mouse embryonic fibroblasts, the oligomerization status of PFK1 is altered and the catalytic activity of PFK1 is decreased. NRX deficiency augments levels of NADPH and reduced glutathione. NRX -/- mouse embryonic fibroblasts are significantly more resistant to oxidative stress than NRX+/+ mouse embryonic fibroblasts | Mus musculus |
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Release 2023.1 (January 2023)
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