Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli strain BLR (DE3) | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
2-methyl-4-amino-5-hydroxymethylpyrimidine | apparent value, in 100 mM triethanolamine or 50 mM potassium phosphate buffer, pH 7.5, 1 mM MgCl2, 500 mM ATP and 100 mM substrate | Plasmodium falciparum | |
0.117 | - |
ATP | apparent value, in 100 mM triethanolamine or 50 mM potassium phosphate buffer, pH 7.5, 1 mM MgCl2, 500 mM ATP and 100 mM substrate | Plasmodium falciparum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
calculated from amino acid sequence | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.108 | - |
using 2-methyl-4-amino-5-hydroxymethylpyrimidine as a substrate, at 37°C | Plasmodium falciparum |
0.169 | - |
using bacimethrin as a substrate, at 37°C | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine | - |
Plasmodium falciparum | ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine | - |
ir | |
ATP + 2-methyl-4-amino-5-phosphomethylpyrimidine | the enzyme shows lower affinity to 2-methyl-4-amino-5-hydroxymethylpyrimidine monophosphate than to 2-methyl-4-amino-5-hydroxymethylpyrimidine | Plasmodium falciparum | ADP + 2-methyl-4-amino-5-diphosphomethylpyrimidine | - |
ir | |
ATP + bacimethrin | - |
Plasmodium falciparum | ADP + ? | - |
? | |
additional information | pyridoxine, pyridoxal, and pyridoxamine are no substrates | Plasmodium falciparum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 35000, gel filtration | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
4-amino-5-hydroxymethyl-2-methylpyrimidine kinase | - |
Plasmodium falciparum |
HMP kinase | - |
Plasmodium falciparum |
HMP/HMP-P kinase | - |
Plasmodium falciparum |
ThiD | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
2-methyl-4-amino-5-hydroxymethylpyrimidine | apparent value, in 100 mM triethanolamine or 50 mM potassium phosphate buffer, pH 7.5, 1 mM MgCl2, 500 mM ATP and 100 mM substrate | Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Plasmodium falciparum |