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Literature summary for 2.7.1.48 extracted from

  • Suzuki, N.N.; Koizumi, K.; Fukushima, M.; Matsuda, A.; Inagaki, F.
    Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase (2004), Structure, 12, 751-764.
    View publication on PubMed

Application

Application Comment Organism
medicine target for antitumor and antiviral drug design Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
truncated form of UCK2 (1-250) in complex with substrates or feedback inhibitors UTP and CTP Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CTP feedback inhibition Homo sapiens
UTP feedback inhibition Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ bound to enzyme Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
analytical ultracentrifugation Homo sapiens
120000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cytidine Homo sapiens rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation ADP + CMP
-
?
ATP + uridine Homo sapiens rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation ADP + UMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZX2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-fluorouridine
-
Homo sapiens ADP + 5-fluorouridine 5'-monophosphate
-
?
ATP + cyclopentenyl-cytosine
-
Homo sapiens ADP + cyclopentenylcytosine 5'-monophosphate
-
?
ATP + cytidine
-
Homo sapiens ADP + CMP
-
?
ATP + cytidine rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation Homo sapiens ADP + CMP
-
?
ATP + uridine
-
Homo sapiens ADP + UMP
-
?
ATP + uridine rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation Homo sapiens ADP + UMP
-
?

Subunits

Subunits Comment Organism
tetramer asymmetric, crystal structure analysis Homo sapiens

Synonyms

Synonyms Comment Organism
More two different enzymes termed UCK1 and UCK2 with 69% sequence identity, expression of UCK 2 but not UCK1 was shown to be enhanced in cancer cells Homo sapiens
uridine-cytidine kinase 2
-
Homo sapiens