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Literature summary for 2.7.1.48 extracted from
- Increased uridine kinase (ATP: uridine 5'-phosphotransferase; EC 2.7.1.48) activity in human and rat tumors (1998), Cancer Biochem. Biophys., 16, 1-15.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.5 | - |
uridine | pH 7.6, 37°C, ovarian carcinoma | Homo sapiens |  |
| 0.8 | - |
ATP | pH 7.6, 37°C, normal liver | Rattus norvegicus | |
| 0.8 | - |
uridine | pH 7.6, 37°C, normal liver | Rattus norvegicus | |
| 5 | - |
ATP | pH 7.6, 37°C, hepatoma cells | Rattus norvegicus | |
| 5 | - |
uridine | pH 7.6, 37°C, hepatoma cells | Rattus norvegicus | |
| 11.5 | - |
uridine | pH 7.6, 37°C, normal ovary | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | 36% of liver activity | Rattus norvegicus | - |
| bone marrow | 184% of liver activity | Rattus norvegicus | - |
| brain | 248% of liver activity | Rattus norvegicus | - |
| heart | 85% of liver activity | Rattus norvegicus | - |
| hepatoma cell | hepatoma 3924A cells, 2fold increase in activity during early log phase of prolifration | Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| lung | 142% of liver activity | Rattus norvegicus | - |
| ovarian cancer cell | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| renal cortex | 160% of liver activity | Rattus norvegicus | - |
| skeletal muscle | 95% of liver activity | Rattus norvegicus | - |
| spleen | 212% of liver activity | Rattus norvegicus | - |
| testis | 140% of liver activity | Rattus norvegicus | - |
| thymus | 468% of liver activity | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
in hepatomas of slow and intermediate growth rates, uridine kinase activity increases 1.5-2.6fold, in hepatomas of rapid growth rates activity increases 5-6fold over that in normal livers | Rattus norvegicus |
| additional information | - |
5-13fold increase of uridine kinase activity in ovarian carcinomas over the activity in normal ovaries | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + uridine | - |
Rattus norvegicus | ADP + UMP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 7.6 | normal liver and hepatoma cells | Rattus norvegicus |
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Release 2023.1 (January 2023)
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