Literature summary for 2.7.1.48 extracted from

Orengo, A.
Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor (1969), J. Biol. Chem., 244, 2204-2209.

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Inhibitors

Inhibitors	Comment	Organism	Structure
CTP	inhibition is partially lost upon ageing of the enzyme and CTP becomes effective as a phosphate donor	Rattus norvegicus
UTP	-	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required for full activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
streptomycin, ammonium sulfate, calcium phosphate, Sephadex G-200	Rattus norvegicus

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + uridine = ADP + UMP	ping-pong mechanism	Rattus norvegicus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
Novikoff ascites tumor cell	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.88	-	-	Rattus norvegicus

Storage Stability

Storage Stability	Organism
-20°C, 50% glycerol, at least 6 months, no loss of activity	Rattus norvegicus
4°C, at least 1 month, no loss of activity	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + uridine	-	Rattus norvegicus	ADP + UMP	-	?
dATP + uridine	-	Rattus norvegicus	dADP + UMP	-	?
dGTP + uridine	-	Rattus norvegicus	dGDP + UMP	-	?
dUTP + uridine	-	Rattus norvegicus	dUDP + UMP	-	?

Synonyms

Synonyms	Comment	Organism
uridine-cytidine kinase	-	Rattus norvegicus

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Release 2023.1 (January 2023)