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Literature summary for 2.7.1.41 extracted from

  • Sidbury, J.B.; Rosenberg, L.L.; Najjar, V.A.
    Muscle glucose-1-phosphate transphosphorylase (1956), J. Biol. Chem., 222, 89-96.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information forward reaction is not activated by ATP, cysteine, histidine, adenylic acid or phosphate Oryctolagus cuniculus

General Stability

General Stability Organism
stable to 3-4 h dialysis against distilled water, prolonged or repeated dialysis inactivates Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
ATP inhibits forward reaction above 2 mM Oryctolagus cuniculus
Cu2+ weak, 0.1 mM Oryctolagus cuniculus
Mg2+ inhibits reverse reaction at 0.5 mM, forward reaction: activation Oryctolagus cuniculus
Mn2+ inhibits forward reaction above 0.5 mM Oryctolagus cuniculus
additional information not inhibited by 8 mM fluoride, cysteine, histidine, adenylic acid or phosphate Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activation of forward reaction, optimal concentration: 1 mM, inhibition of reverse reaction, Mg2+ forms a complex with the product glucose-1,6-bisphosphate Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial, not separated from phosphoglucomutase Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle muscles of back and hind legs Oryctolagus cuniculus
-

Storage Stability

Storage Stability Organism
6°C, within 1 week, inactivation Oryctolagus cuniculus
frozen, partially purified preparation, at least 4 weeks, stable Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 1-phosphate + D-glucose 1-phosphate
-
Escherichia coli D-glucose + D-glucose 1,6-bisphosphate
-
?
D-glucose 1-phosphate + D-glucose 1-phosphate
-
Oryctolagus cuniculus D-glucose + D-glucose 1,6-bisphosphate
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
forward reaction, in the presence of Mg2+ Oryctolagus cuniculus