Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.40 extracted from

  • Prasannan, C.B.; Villar, M.T.; Artigues, A.; Fenton, A.W.
    Identification of regions of rabbit muscle pyruvate kinase important for allosteric regulation by phenylalanine, detected by H/D exchange mass spectrometry (2013), Biochemistry, 52, 1998-2006.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.40

Inhibitors

Inhibitors Comment Organism Structure
additional information alanine is a nonallosteric analogue of phenylalanine, it binds competitively with phenylalanine but elicits a negligible allosteric inhibition, i.e., a negligible reduction in the affinity of the muscle enzyme for the substrate, phosphoenolpyruvate Oryctolagus cuniculus
phenylalanine allosteric inhibitor, regions of pyruvate kinase important for allosteric regulation by phenylalanine, H/D exchange mass spectrometry, overview Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ binds at the active site Oryctolagus cuniculus
Mn2+ required, binds at the active site Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate Oryctolagus cuniculus
-
 ADP + phosphoenolpyruvate
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate
-
 Oryctolagus cuniculus ADP + phosphoenolpyruvate
-
 ?

Subunits

Subunits Comment Organism
homotetramer crystal structure Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
rM1-PYK
-
 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus

General Information

General Information Comment Organism
additional information allosteric mechanism of rM1-PYK, overview Oryctolagus cuniculus