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Literature summary for 2.7.1.40 extracted from

  • Spoden, G.A.; Morandell, D.; Ehehalt, D.; Fiedler, M.; Jansen-Duerr, P.; Hermann, M.; Zwerschke, W.
    The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2 (2009), J. Cell. Biochem., 107, 293-302.
    View publication on PubMed
Search for more literature for 2.7.1.40

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus overexpression of PIAS3 leads to nuclear localization of M2-PK and the co-localization of this enzyme with PIAS3 in the nucleus Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 most of the protein recognized by the anti-M2-PK antibodies runs at 58000 Da, SDS-PAGE Homo sapiens
80000
-
 M2-PK-SUMO-1 conjugate, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
sumoylation PIAS3 slightly enhances M2-PK sumoylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
 Homo sapiens ATP + pyruvate
-
 ?
additional information the SUMO-E3 ligase protein PIAS3 (inhibitor of activated STAT3) physically interacts with M2-PK and its isoenzyme M1-PK Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ATP/pyruvate O'-phosphotransferase
-
 Homo sapiens
M1-PK isozyme Homo sapiens
M2-PK isozyme Homo sapiens
pyruvate kinase M2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Homo sapiens