Application | Comment | Organism |
---|---|---|
medicine | correlation betwen severity of pyruvate kinase-deficiency and extent of protection against malaria | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G338D | loss-of-function mutation in the erythrocyte-specific pyruvate kinase gene resulting in hemolytic anemia with dramatic reduction in the half-life of eryhtrocytes. Mice carrying the mutation are highly resistant to infection with Plasmodium chabaudi. Mutation G338D has more severe effects on pyruvate kinase as well as higher protection against malaria infection than less severe mutation I90N | Mus musculus |
I90N | loss-of-function mutation in the reythrocyte-specific pyruvate kinase gene, protective against blood-stage malaria. Mutation G338D has more severe effects on pyruvate kinase as well as higher protection against malaria infection than less severe mutation I90N | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
erythrocyte-specific pyruvate kinase gene PKLR | - |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
Pklr | - |
Mus musculus |