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Literature summary for 2.7.1.40 extracted from

  • Feksa, L.R.; Cornelio, A.; Dutra-Filho, C.S.; De Souza Wyse, A.T.; Wajner, M.; Wannmacher, C.M.
    Inhibition of pyruvate kinase activity by cystine in brain cortex of rats (2004), Brain Res., 1012, 93-100.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cystine inhibits by two different mechanisms, one through the competition with ADP and phosphoenolpyruvate, and the other non-competitively, probable through oxidation of the thiol groups of the enzyme. GSH and cysteamine fully prevent and reverse the inhibition caused by cystine Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
phosphoenolpyruvate
-
Rattus norvegicus
1.3
-
ADP
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
cerebral cortex
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
Rattus norvegicus ATP + pyruvate
-
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