Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | Mus musculus | a step in the production of farnesyldiphosphate and geranylgeranyl diphosphate, overview | ADP + (R)-5-phosphomevalonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
MC3T3-E1 cell | a clonal osteoblast-like mouse calvarial cell line | Mus musculus | - |
osteoblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | - |
Mus musculus | ADP + (R)-5-phosphomevalonate | - |
? | |
ATP + (R)-mevalonate | a step in the production of farnesyldiphosphate and geranylgeranyl diphosphate, overview | Mus musculus | ADP + (R)-5-phosphomevalonate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MVK | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | parathyroid hormone, from human source comprising residues 1-34, suppresses the mevalonate kinase in osteoblastic cells | down |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is part of the mevalonate pathway leading to the production of farnesyl diphosphate and geranylgeranyl diphosphate, overview | Mus musculus |
additional information | mevalonate kinase and Rho kinase are involved in regulation of BMP-2 mRNA expression, inhibition of both enzymes in osteoblastic MC3T3-E1 cells upregulates BMP-2 mRNA expression | Mus musculus |