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Literature summary for 2.7.1.36 extracted from

  • Takase, H.; Yano, S.; Yamaguchi, T.; Kanazawa, I.; Hayashi, K.; Yamamoto, M.; Yamauchi, M.; Sugimoto, T.
    Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells (2009), Horm. Metab. Res., 41, 861-865.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (R)-mevalonate Mus musculus a step in the production of farnesyldiphosphate and geranylgeranyl diphosphate, overview ADP + (R)-5-phosphomevalonate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
Mus musculus
-
MC3T3-E1 cell a clonal osteoblast-like mouse calvarial cell line Mus musculus
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osteoblast
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-mevalonate
-
Mus musculus ADP + (R)-5-phosphomevalonate
-
?
ATP + (R)-mevalonate a step in the production of farnesyldiphosphate and geranylgeranyl diphosphate, overview Mus musculus ADP + (R)-5-phosphomevalonate
-
?

Synonyms

Synonyms Comment Organism
MVK
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus parathyroid hormone, from human source comprising residues 1-34, suppresses the mevalonate kinase in osteoblastic cells down

General Information

General Information Comment Organism
metabolism the enzyme is part of the mevalonate pathway leading to the production of farnesyl diphosphate and geranylgeranyl diphosphate, overview Mus musculus
additional information mevalonate kinase and Rho kinase are involved in regulation of BMP-2 mRNA expression, inhibition of both enzymes in osteoblastic MC3T3-E1 cells upregulates BMP-2 mRNA expression Mus musculus