Literature summary for 2.7.1.35 extracted from

Laine-Cessac, P.; Cailleux, A.; Allain, P.
Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs (1997), Biochem. Pharmacol., 54, 863-870.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cycloserine	0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 42% inhibition	Homo sapiens
D-penicillamine	0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 20% inhibition	Homo sapiens
dopamine	0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 52% inhibition	Homo sapiens
isoniazid	0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 81% inhibition	Homo sapiens
levodopa	0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 16% inhibition	Homo sapiens
muzolimine	0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 27% inhibition	Homo sapiens
progabide	0.1 mM, inhibits using either pyridoxamine or pyridoxal as substrate	Homo sapiens
theophylline	0.1 mM, inhibits using either pyridoxamine or pyridoxal as substrate, 86% inhibition of reaction with pyridoxal, 88% inhibition of reaction with pyridoxamine	Homo sapiens
Thiamphenicol	0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 31% inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + pyridoxal	-	Homo sapiens	ADP + pyridoxal 5'-phosphate	-	?
ATP + pyridoxamine	-	Homo sapiens	ADP + pyridoxamine 5'-phosphate	-	?

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Release 2023.1 (January 2023)