Literature summary for 2.7.1.33 extracted from

Ishibashi, T.; Tomita, H.; Yokooji, Y.; Morikita, T.; Watanabe, B.; Hiratake, J.; Kishimoto, A.; Kita, A.; Miki, K.; Imanaka, T.; Atomi, H.
A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea (2012), Extremophiles, 16, 819-828.

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Cloned(Commentary)

Cloned (Comment)	Organism
the TK2141 gene encoding PoK, with a His6-Tag on its N-terminus, is overexpressed in Thermococcus kodakarensis	Thermococcus kodakarensis

Inhibitors

Inhibitors	Comment	Organism	Structure
4-phosphopantoate	substrate inhibition	Thermococcus kodakarensis
ATP	substrate inhibition	Thermococcus kodakarensis
additional information	feedback inhibition by CoA/acetyl-CoA and product inhibition by 4'-phosphopantothenate are not observed	Thermococcus kodakarensis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (R)-4-phosphopantoate + beta-alanine	Thermococcus kodakarensis	the enzyme is involved in coenzyme A biosynthesis in the archaea	AMP + diphosphate + (R)-4'-phosphopantothenate	-	?

Organism

Organism	UniProt	Comment	Textmining
Thermococcus kodakarensis	Q5JHF1	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Thermococcus kodakarensis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (R)-4-phosphopantoate + beta-alanine	the enzyme is involved in coenzyme A biosynthesis in the archaea	Thermococcus kodakarensis	AMP + diphosphate + (R)-4'-phosphopantothenate	-	?

Synonyms

Synonyms	Comment	Organism
4-phosphopantoate	non-competitive	Thermococcus kodakarensis
PoK	-	Thermococcus kodakarensis
TK2141	-	Thermococcus kodakarensis

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
75	-	assay at	Thermococcus kodakarensis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Thermococcus kodakarensis

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Release 2023.1 (January 2023)