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Literature summary for 2.7.1.33 extracted from

  • Awasthy, D.; Ambady, A.; Bhat, J.; Sheikh, G.; Ravishankar, S.; Subbulakshmi, V.; Mukherjee, K.; Sambandamurthy, V.; Sharma, U.
    Essentiality and functional analysis of type I and type III pantothenate kinases of Mycobacterium tuberculosis (2010), Microbiology, 156, 2691-2701.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DV62 and BL21(DE3) cells Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv (ATCC 27294)
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex pg 200 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantothenate
-
Mycobacterium tuberculosis ADP + (R)-4'-phosphopantothenate
-
?
ATP + (R)-pantothenate
-
Mycobacterium tuberculosis H37Rv (ATCC 27294) ADP + (R)-4'-phosphopantothenate
-
?

Synonyms

Synonyms Comment Organism
CoaA isoform, CoaA is the essential pantothenate kinase in Mycobacterium tuberculosis Mycobacterium tuberculosis
CoaX isoform Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function CoaA is essential for survival of Mycobacterium tuberculosis. The coax gene is unable to complement the loss of gene coaA. CoaX lacks pantothenate kinase activity in vitro and is not required for survival in macrophages and mice Mycobacterium tuberculosis