Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cholesterol | about 125% activity at 0.1 mM | Homo sapiens | |
glyburide | - |
Homo sapiens | |
glyburide | isoform PanK1b is activated by glyburide | Homo sapiens | |
additional information | isoform PanK3 is not activated by 1,4-naphthoquinone and phenylmercuric acid | Homo sapiens | |
O-oleoylcarnitine | 140% activation at 0.1 mM | Homo sapiens | |
O-palmitoylcarnitine | 120% activation at 0.1 mM | Homo sapiens | |
oleoylethanolamide | 120% activation at 0.1 mM | Homo sapiens | |
tamoxifen | 140% activation at 0.1 mM | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A267F | catalytically inactive | Homo sapiens |
A269F | catalytically inactive | Homo sapiens |
R207A | catalytically inactive | Homo sapiens |
S195V | the mutant is insensitive to acetyl-CoA and has a KM defect for pantothenate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide | - |
Homo sapiens | |
acetyl-CoA | complete inhibition of isoform PanK3 at 0.008 mM | Homo sapiens | |
ADP | competitive inhibitor of isoform PanK3 with respect to ATP1 and a mixed-type inhibitor with respect to pantothenate | Homo sapiens | |
chloranil | - |
Homo sapiens | |
dehydroisoandrosterone | about 30% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
Dehydroisoandrosterone sulfate | about 8% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
ephedrine hydrochloride | - |
Homo sapiens | |
estradiol | about 80% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
Estradiol sulfate | about 90% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
Estrone sulfate | about 50% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
Fusidic acid | - |
Homo sapiens | |
glipizide | - |
Homo sapiens | |
glyburide | - |
Homo sapiens | |
GW5074 | - |
Homo sapiens | |
Hexachlorophene | - |
Homo sapiens | |
MCC-555 | MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b; MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b | Homo sapiens | |
additional information | isoform PanK3 is not inhibited by estrone | Homo sapiens | |
pioglitazone hydrochloride | - |
Homo sapiens | |
pregnenolone sulfate | about 10% residual activity at 0.1 mM (isoform PanK3); about 92% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
Psi-rhodomyrtoxin | - |
Homo sapiens | |
Reactive blue 2 | - |
Homo sapiens | |
Ro 41-0960 | - |
Homo sapiens | |
rosiglitazone | - |
Homo sapiens | |
tamoxifen | - |
Homo sapiens | |
tolfenamic acid | - |
Homo sapiens | |
tyrphostin AG 528 | - |
Homo sapiens | |
tyrphostin AG 808 | - |
Homo sapiens | |
WIN 62577 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
(R)-pantothenate | isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | |
0.311 | - |
ATP | isoform PanK3, at pH 7.5 and 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q9H999 | isoform PanK3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HepG2/C3A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-pantothenate | - |
Homo sapiens | ADP + (R)-4'-phosphopantothenate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PanK1b | isoform | Homo sapiens |
PanK2 | isoform | Homo sapiens |
PanK3 | isoform | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Fusidic acid | |
0.0004 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | 1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide | |
0.0007 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | WIN 62577 | |
0.001 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | pioglitazone hydrochloride | |
0.0013 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Reactive blue 2 | |
0.0016 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | ephedrine hydrochloride | |
0.0016 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Psi-rhodomyrtoxin | |
0.0017 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | rosiglitazone | |
0.0025 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | pregnenolone sulfate | |
0.003 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | tyrphostin AG 528 | |
0.0035 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Dehydroisoandrosterone sulfate | |
0.0039 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Ro 41-0960 | |
0.0052 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | glipizide | |
0.0059 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | chloranil | |
0.0068 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | glyburide | |
0.0088 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Hexachlorophene | |
0.009 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | tyrphostin AG 808 | |
0.0092 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | GW5074 | |
0.0092 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | tolfenamic acid |
General Information | Comment | Organism |
---|---|---|
metabolism | pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis | Homo sapiens |