Any feedback?
Literature summary for 2.7.1.33 extracted from
- Coenzyme A biosynthesis: an antimicrobial drug target (2008), FEMS Microbiol. Rev., 32, 56-106.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Staphylococcus aureus |
- |
Mycobacterium tuberculosis |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CoA | competitive | Escherichia coli |  |
| additional information | inhibition by CoA thioesters | Escherichia coli |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.027 | - |
ATP | - |
Staphylococcus aureus | |
| 0.093 | - |
pantothenate | - |
Staphylococcus aureus | |
| 0.136 | - |
pantothenate | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pantothenate | Escherichia coli | first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo | ADP + (R)-4'-phosphopantothenate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Staphylococcus aureus |
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pantothenate | - |
Staphylococcus aureus | ADP + (R)-4'-phosphopantothenate | - |
? | |
| ATP + pantothenate | - |
Escherichia coli | ADP + (R)-4'-phosphopantothenate | - |
? | |
| ATP + pantothenate | - |
Mycobacterium tuberculosis | ADP + (R)-4'-phosphopantothenate | - |
? | |
| ATP + pantothenate | first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo | Escherichia coli | ADP + (R)-4'-phosphopantothenate | - |
? | |
| ATP + pantothenate | - |
Mycobacterium tuberculosis | ADP + D-4'-phosphopantothenate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CoaA | - |
Staphylococcus aureus |
| CoaA | - |
Escherichia coli |
| CoaA | - |
Mycobacterium tuberculosis |
| PanK | - |
Staphylococcus aureus |
| PanK | - |
Escherichia coli |
| PanK | - |
Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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