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Literature summary for 2.7.1.33 extracted from

  • Kumar, P.; Chhibber, M.; Surolia, A.
    How pantothenol intervenes in coenzyme-A biosynthesis of Mycobacterium tuberculosis (2007), Biochem. Biophys. Res. Commun., 361, 903-909.
    View publication on PubMed
Search for more literature for 2.7.1.33

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
CoA
-
 Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 ATP 25°C, pH 7.8, determined by isothermal titration calorimetry Mycobacterium tuberculosis
0.1
-
 pantothenate 25°C, pH 7.8, determined from coupled assay Mycobacterium tuberculosis
0.18
-
 pantothenate 25°C, pH 7.8, determined by isothermal titration calorimetry Mycobacterium tuberculosis
0.25
-
 pantothenol 25°C, pH 7.8, determined by isothermal titration calorimetry Mycobacterium tuberculosis
0.28
-
 pantothenol 25°C, pH 7.8, determined from coupled assay Mycobacterium tuberculosis
0.375
-
 ATP 25°C, pH 7.8, determined from coupled assay Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPA7
-
-
Mycobacterium tuberculosis H37Rv P9WPA7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pantothenate
-
 Mycobacterium tuberculosis ADP + 4'-phosphopantothenate
-
 ?
ATP + pantothenate
-
 Mycobacterium tuberculosis H37Rv ADP + 4'-phosphopantothenate
-
 ?
ATP + pantothenol
-
 Mycobacterium tuberculosis ADP + 4'-phosphopantothenol
-
 ?
ATP + pantothenol
-
 Mycobacterium tuberculosis H37Rv ADP + 4'-phosphopantothenol
-
 ?

Synonyms

Synonyms Comment Organism
MtCoaA
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.38
-
 pantothenol 25°C, pH 7.8, determined by isothermal titration calorimetry Mycobacterium tuberculosis
0.4
-
 pantothenol 25°C, pH 7.8, determined from coupled assay Mycobacterium tuberculosis
0.61
-
 pantothenate 25°C, pH 7.8, determined from coupled assay Mycobacterium tuberculosis
0.62
-
 pantothenate 25°C, pH 7.8, determined by isothermal titration calorimetry Mycobacterium tuberculosis
0.62
-
 ATP 25°C, pH 7.8, determined from coupled assay Mycobacterium tuberculosis
0.65
-
 ATP 25°C, pH 7.8, determined by isothermal titration calorimetry Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
 CoA
-
 Mycobacterium tuberculosis