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Literature summary for 2.7.1.33 extracted from

  • Hong, B.S.; Yun, M.K.; Zhang, Y.M.; Chohnan, S.; Rock, C.O.; White, S.W.; Jackowski, S.; Park, H.W.; Leonardi, R.
    Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties (2006), Structure, 14, 1251-1261.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Staphylococcus aureus
-
Pseudomonas aeruginosa

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method using 28% (w/v) PEG 2000 mM and 0.1M Bis-Tris (pH 6.5), at 18°C Pseudomonas aeruginosa
sitting drop vapour diffusion method using 28% (w/v) PEG 2 M and 0.1 M Bis-Tris (pH 6.5), at 18°C Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
D101A reduced enzymatic activity Pseudomonas aeruginosa
D121A reduced enzymatic activity Pseudomonas aeruginosa
D6A reduced enzymatic activity Staphylococcus aureus
E70A reduced enzymatic activity Staphylococcus aureus
H156A slightly increased enzymatic activity Pseudomonas aeruginosa
K13A reduced enzymatic activity Staphylococcus aureus
K13A reduced enzymatic activity Pseudomonas aeruginosa
L11A reduced enzymatic activity Staphylococcus aureus
L263P reduced enzymatic activity Staphylococcus aureus
N9G strongly reduced enzymatic activity Pseudomonas aeruginosa
T10A reduced enzymatic activity Staphylococcus aureus
T157A reduced enzymatic activity Pseudomonas aeruginosa
Y137A reduced enzymatic activity Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ 0.06-0.12 mM Staphylococcus aureus
K+ 0.06-0.12 mM Pseudomonas aeruginosa
Mg2+ required Staphylococcus aureus
Mg2+ required Pseudomonas aeruginosa
NH4+ induces a 5fold higher activation than either K+ or Rb+ Staphylococcus aureus
NH4+ induces a 5fold higher activation than either K+ or Rb+ Pseudomonas aeruginosa
Rb+
-
Staphylococcus aureus
Rb+
-
Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HWC1
-
-
Staphylococcus aureus Q6G7I0
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Staphylococcus aureus
-
Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantothenate
-
Staphylococcus aureus ADP + (R)-4'-phosphopantothenate
-
?
ATP + (R)-pantothenate
-
Pseudomonas aeruginosa ADP + (R)-4'-phosphopantothenate
-
?

Subunits

Subunits Comment Organism
dimer x-ray crystallography Staphylococcus aureus
dimer x-ray crystallography Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
CoaA
-
Staphylococcus aureus
CoaA
-
Pseudomonas aeruginosa
type II pantothenate kinase
-
Staphylococcus aureus
type III pantothenate kinase
-
Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
ATP
-
Staphylococcus aureus
ATP
-
Pseudomonas aeruginosa