Literature summary for 2.7.1.33 extracted from

Lehane, A.M.; Marchetti, R.V.; Spry, C.; van Schalkwyk, D.A.; Teng, R.; Kirk, K.; Saliba, K.J.
Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite (2007), J. Biol. Chem., 282, 25395-25405.

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Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-CoA	effective inhibitor	Plasmodium falciparum
CoA	IC50: 0.2 mM	Plasmodium falciparum
coenzyme A	feedback inhibition regulates pantothenol uptake. Furosemide reduces this inherent feedback inhibition by competing with coenzyme A for binding to pantothenate kinase, thereby increasing pantothenol uptake	Plasmodium falciparum
malonyl-CoA	effective inhibitor	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-
Plasmodium falciparum	-	strains 3D7 and FAF6	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (R)-pantothenate	-	Plasmodium falciparum	ADP + (R)-4'-phosphopantothenate	-	?

Synonyms

Synonyms	Comment	Organism
PanK	-	Plasmodium falciparum

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Plasmodium falciparum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.2	-	IC50: 0.2 mM	Plasmodium falciparum	CoA

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Release 2023.1 (January 2023)