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Literature summary for 2.7.1.33 extracted from

  • Hartig, M.B.; Hoertnagel, K.; Garavaglia, B.; Zorzi, G.; Kmiec, T.; Klopstock, T.; Rostasy, K.; Svetel, M.; Kostic, V.S.; Schuelke, M.; Botz, E.; Weindl, A.; Novakovic, I.; Nardocci, N.; Prokisch, H.; Meitinger, T.
    Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation (2006), Ann. Neurol., 59, 248-256.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain ts9 Homo sapiens

Protein Variants

Protein Variants Comment Organism
G521R loss of enzyme activity Homo sapiens
T528M no effect on PANK2 activity or stability Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
SDS-PAGE, mature protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZ23
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantothenate
-
Homo sapiens ADP + (R)-4'-phosphopantothenate
-
?

Synonyms

Synonyms Comment Organism
PanK2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens