Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | activation | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetoacetyl-CoA | - |
Escherichia coli | |
acetyl-CoA | - |
Escherichia coli | |
ADP | - |
Escherichia coli | |
AMP | - |
Escherichia coli | |
CoA | in vitro; in vivo; kinetics | Escherichia coli | |
dephospho-CoA | not | Escherichia coli | |
malonyl-CoA | - |
Escherichia coli | |
additional information | not inhibitory: 3',5'-ADP; not inhibitory: cAMP, NADH, NADPH, CoA:glutathione disulfide; not inhibitory: NAD+ | Escherichia coli | |
palmitoyl-CoA | - |
Escherichia coli | |
pantetheine 4'-phosphate | not | Escherichia coli | |
succinyl-CoA | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
pantothenate | - |
Escherichia coli | |
0.225 | - |
ATP | pH 7.4, 25°C | Escherichia coli | |
0.225 | - |
ATP | ATP in form of MgATP2- | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Escherichia coli | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-pantothenate | Escherichia coli | first and rate-controlling reaction of CoA-biosynthesis | ADP + D-4'-phosphopantothenate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
K-12 strains UB 1005, SJ16, DV1 | - |
Purification (Comment) | Organism |
---|---|
strain SJ16, partial | Escherichia coli |
Storage Stability | Organism |
---|---|
-20°C, partially purified preparation, several months | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-pantothenate | - |
Escherichia coli | ADP + (R)-4'-phosphopantothenate | - |
? | |
ATP + D-pantothenate | poor phosphate donor: alpha,beta-methyleneadenosine 5'-triphosphate | Escherichia coli | ADP + D-4'-phosphopantothenate | - |
? | |
ATP + D-pantothenate | transfers the gamma-phosphate of ATP to pantothenate | Escherichia coli | ADP + D-4'-phosphopantothenate | - |
? | |
ATP + D-pantothenate | first and rate-controlling reaction of CoA-biosynthesis | Escherichia coli | ADP + D-4'-phosphopantothenate | - |
? | |
GTP + pantothenate | phosphorylation at 20% the rate of ATP | Escherichia coli | GDP + D-4'-phosphopantothenate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Escherichia coli |