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Literature summary for 2.7.1.29 extracted from
- Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR (2005), EMBO J., 24, 283-293.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the DhaR transcription factor stimulates the transcription of the dhaKLM operon from a sigma70 promotor and autorepresses expression of DhaR | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + glycerone | Escherichia coli | regulation involving de-/phosphorylation, and the 3 subunits with ADP and transcription factor DhaR, overview | pyruvate + glycerone phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P76015 | subunit DhaK | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + glycerone | - |
Escherichia coli | pyruvate + glycerone phosphate | i.e. dihydroxyacetone phosphate | ? | |
| phosphoenolpyruvate + glycerone | regulation involving de-/phosphorylation, and the 3 subunits with ADP and transcription factor DhaR, overview | Escherichia coli | pyruvate + glycerone phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | enzyme exists of 3 subunit DhaK, DhaM, and DhaL: DhaK contains the dihydroxyacetone phosphate binding site, DhaL contains ADP as cofactor for phosphate double displacement from DhaM to dihydroxyacetone phosphate, and DhaM provides a phospho-histidine relay between phosphoenolpyruvate and DhaL-ADP | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHA kinase | - |
Escherichia coli |
| dihydroxyacetone kinase | - |
Escherichia coli |
| More | dihydroxyacetoe phosphate kinases exist in 2 different groups, one utilizing ATP as phosphate donor, the other utilizing phosphoenolpyrivate | Escherichia coli |
| phosphoenolpyruvate carbohydrate phosphotransferase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | dependent on | Escherichia coli | |
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