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Literature summary for 2.7.1.26 extracted from

  • Grill, S.; Busenbender, S.; Pfeiffer, M.; Koehler, U.; Mack, M.
    The bifunctional flavokinase/flavin adenine dinucleotide synthetase from Streptomyces davawensis produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin (2008), J. Bacteriol., 190, 1546-1553.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.26

Cloned(Commentary)

Cloned (Comment) Organism
overproduced in Escherichia coli Streptomyces davaonensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
 roseoflavin 37°C Bacillus subtilis
0.03
-
 roseoflavin 37°C Streptomyces davaonensis
0.04
-
 riboflavin 37°C Streptomyces davaonensis
0.055
-
 riboflavin 37°C Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptomyces davaonensis the bifunctional flavokinase/flavin adenine dinucleotide synthetase produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Streptomyces davaonensis A3FM23
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Streptomyces davaonensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + riboflavin
-
 Bacillus subtilis ADP + FMN
-
 ?
ATP + riboflavin
-
 Streptomyces davaonensis ADP + FMN
-
 ?
ATP + roseoflavin
-
 Bacillus subtilis ADP + roseoflavin 5'-phosphate
-
 ?
ATP + roseoflavin
-
 Streptomyces davaonensis ADP + roseoflavin 5'-phosphate
-
 ?
additional information the bifunctional flavokinase/flavin adenine dinucleotide synthetase produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin Streptomyces davaonensis ?
-
 ?

Synonyms

Synonyms Comment Organism
flavokinase/FAD synthetase
-
 Bacillus subtilis
flavokinase/FAD synthetase
-
 Streptomyces davaonensis
flavokinase/flavin adenine dinucleotide synthetase bifunctional enzyme EC 2.7.1.26/EC 2.7.2.2 Bacillus subtilis
flavokinase/flavin adenine dinucleotide synthetase bifunctional enzyme EC 2.7.1.26/EC 2.7.2.2 Streptomyces davaonensis
RibC
-
 Bacillus subtilis
RibC
-
 Streptomyces davaonensis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.3
-
 riboflavin 37°C Streptomyces davaonensis
0.4
-
 roseoflavin 37°C Bacillus subtilis
0.5
-
 roseoflavin 37°C Streptomyces davaonensis
0.7
-
 riboflavin 37°C Bacillus subtilis