Protein Variants | Comment | Organism |
---|---|---|
G427A | - |
Homo sapiens |
G79R | reduced APS kinase activity | Mus musculus |
H425A | - |
Homo sapiens |
H428A | - |
Homo sapiens |
N426K | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine 5-phosphosulfate | Mus musculus | enzyme is involved in sulfation of cartilaginous chondroitin sulfate, reduced enzyme activity causes brachymorphism | ADP + 3'-phosphoadenosine 5'-phosphosulfate | - |
? | |
ATP + adenosine 5-phosphosulfate | Homo sapiens | PAPSS 1 is essential for the sulfonation of mucin like glycoproteins such as GlyCAM-1, CD34 and MAdCAM-1 in high endothelial venules | ADP + 3'-phosphoadenosine 5'-phosphosulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Cavia porcellus | O54820 | guinea pig, isoenzyme PAPSS 1 | - |
Danio rerio | Q802U9 | zebra fish | - |
Drosophila melanogaster | Q9VW48 | - |
- |
Homo sapiens | - |
- |
- |
Homo sapiens | O43252 | PAPSS 1 | - |
Homo sapiens | O95340 | isoenzyme PAPSS 2 | - |
Homo sapiens | O95340 | isoenzyme PAPSS 2b, splice variant of PAPSS2, several SNPs and polymorphisms are identified with reference to PAPSS 1 and 2 | - |
Mus musculus | - |
isoenzymes PAPS 1 and 2 | - |
Takifugu rubripes | Q90XY2 | puffer fish | - |
Urechis caupo | Q27128 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | high expression of PAPSS 1 | Homo sapiens | - |
cartilage | - |
Homo sapiens | - |
cartilage | high expression of PAPSS 2 | Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | predominantly PAPS2 | Homo sapiens | - |
liver | high expression of PAPSS 2 | Homo sapiens | - |
skin | PAPSS 1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Mus musculus | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Homo sapiens | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Urechis caupo | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Cavia porcellus | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Candida elegans | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Drosophila melanogaster | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Danio rerio | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | i.e. adenylylsulfate or APS | Takifugu rubripes | ADP + 3'-phosphoadenosine 5'-phosphosulfate | i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate | ? | |
ATP + adenosine 5-phosphosulfate | enzyme is involved in sulfation of cartilaginous chondroitin sulfate, reduced enzyme activity causes brachymorphism | Mus musculus | ADP + 3'-phosphoadenosine 5'-phosphosulfate | - |
? | |
ATP + adenosine 5-phosphosulfate | PAPSS 1 is essential for the sulfonation of mucin like glycoproteins such as GlyCAM-1, CD34 and MAdCAM-1 in high endothelial venules | Homo sapiens | ADP + 3'-phosphoadenosine 5'-phosphosulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAPSS 1 | - |
Homo sapiens |