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Literature summary for 2.7.1.23 extracted from

  • Bieganowski, P.; Seidle, H.F.; Wojcik, M.; Brenner, C.
    Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions (2006), J. Biol. Chem., 281, 22439-22445.
    View publication on PubMed
Search for more literature for 2.7.1.23

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as N-terminally His-tagged fusion Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Saccharomyces cerevisiae 5737
-
cytosol
-
 Saccharomyces cerevisiae 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NAD+ Saccharomyces cerevisiae Utr1 is responsible for essentially all of the NAD/NADH kinase activity resident in the cytoplasm ADP + NADP+
-
 ?
ATP + NAD+ Saccharomyces cerevisiae Yef1 contributes very slightly to total NAD and NADH kinase activities in vivo ADP + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P21373
-
-
Saccharomyces cerevisiae P32622
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NAD+ Utr1 is responsible for essentially all of the NAD/NADH kinase activity resident in the cytoplasm Saccharomyces cerevisiae ADP + NADP+
-
 ?
ATP + NAD+ Yef1 contributes very slightly to total NAD and NADH kinase activities in vivo Saccharomyces cerevisiae ADP + NADP+
-
 ?
ATP + NAD+ specific activity is 43fold higher than with NADH and ATP Saccharomyces cerevisiae ADP + NADP+
-
 ?
ATP + NAD+ specific activity is about 3fold higher than with NADH Saccharomyces cerevisiae ADP + NADP+
-
 ?
ATP + NADH specific activity is 43fold lower than with NAD+ and ATP Saccharomyces cerevisiae ADP + NADPH
-
 ?
ATP + NADH specific activity is about 3fold lower than with NAD+ and ATP Saccharomyces cerevisiae ADP + NADPH
-
 ?
CTP + NAD+ specific activity is 16.5fold lower than with NAD+ and ATP Saccharomyces cerevisiae CDP + NADP+
-
 ?
CTP + NAD+ specific activity is 7fold lower than with NAD+ and ATP Saccharomyces cerevisiae CDP + NADP+
-
 ?
CTP + NADH specific activity is 13.2fold lower than with NADH and ATP Saccharomyces cerevisiae CDP + NADPH
-
 ?
CTP + NADH specific activity is 2.4fold lower than with NADH and ATP Saccharomyces cerevisiae CDP + NADPH
-
 ?
dATP + NAD+ specific activity is 2.6fold lower than with ATP and NAD+ Saccharomyces cerevisiae dADP + NADP+
-
 ?
dATP + NAD+ specific activity is similar to reaction with ATP and NAD+ Saccharomyces cerevisiae dADP + NADP+
-
 ?
dCTP + NAD+ specific activity is 11fold lower than with ATP and NAD+ Saccharomyces cerevisiae dCDP + NADP+
-
 ?
dCTP + NAD+ specific activity is 3.3fold lower than with ATP and NAD+ Saccharomyces cerevisiae dCDP + NADP+
-
 ?
dGTP + NAD+ specific activity is 11fold lower than with ATP and NAD+ Saccharomyces cerevisiae dGDP + NADP+
-
 ?
dGTP + NAD+ specific activity is 13.2fold lower than with ATP and NAD+ Saccharomyces cerevisiae dGDP + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
NAD kinase
-
 Saccharomyces cerevisiae
Utr
-
 Saccharomyces cerevisiae
YEF1 low specific activity cytosolic NAD kinase Saccharomyces cerevisiae