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Literature summary for 2.7.1.23 extracted from
- NAD+ kinase-a review (1985), Int. J. Biochem., 17, 1-11.
General Stability
| General Stability | Organism |
|---|---|
| liver enzyme can be dialyzed at 4°C for at least 16 h with loss of activity and is also stable towards freezing and thawing | Columba sp. |
| liver preparation is unstable to dialysis and repeated freezing and thawing | Oryctolagus cuniculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-(bromoacetyl)pyridine | - |
Columba sp. |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Columba sp. | 5737 | - |
| cytoplasm | the enzyme from skeletal muscle is susceptible to seasonal alterations: in autumn and winter, NADP+ synthesis proceeds maximally in the cytoplasm, in spring, higher activity is found in the mitochondrial fraction | Oryctolagus cuniculus | 5737 | - |
| mitochondrion | the enzyme from skeletal muscle is susceptible to seasonal alterations: in autumn and winter, NADP+ synthesis proceeds maximally in the cytoplasm, in spring, higher activity is found in the mitochondrial fraction | Oryctolagus cuniculus | 5739 | - |
| soluble | - |
Oryctolagus cuniculus | - |
- |
| soluble | - |
Spinacia oleracea | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Achromobacter aceris | - |
- |
- |
| Azotobacter vinelandii | - |
- |
- |
| Bos taurus | - |
- |
- |
| Columba sp. | - |
- |
- |
| Corynebacterium ammoniagenes | - |
- |
- |
| Cyberlindnera jadinii | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | O95544 | - |
- |
| Nicotiana tabacum | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Pisum sativum | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Spinacia oleracea | - |
- |
- |
| Triatoma infestans | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| embryo | fibroblast | Columba sp. | - |
| erythrocyte | - |
Homo sapiens | - |
| fibroblast | - |
Homo sapiens | - |
| fibroblast | from embryo | Columba sp. | - |
| heart | - |
Columba sp. | - |
| kidney | - |
Oryctolagus cuniculus | - |
| leaf | - |
Spinacia oleracea | - |
| leaf | - |
Pisum sativum | - |
| leaf | - |
Nicotiana tabacum | - |
| liver | - |
Gallus gallus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Columba sp. | - |
| placenta | - |
Homo sapiens | - |
| polymorphonuclear leukocyte | - |
Homo sapiens | - |
| retina | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Oryctolagus cuniculus | - |
| thyroid gland | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 80% loss of activity after 7 days, no loss of activity after 5 days in presence of serum albumin | Cyberlindnera jadinii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-acetyl pyridineadenine dinucleotide | - |
Columba sp. | ? | - |
? | |
| ATP + NAD+ | - |
Gallus gallus | ADP + NADP+ | - |
? | |
| ATP + NAD+ | - |
Cyberlindnera jadinii | ADP + NADP+ | - |
? | |
| ATP + NAD+ | - |
Saccharomyces cerevisiae | ADP + NADP+ | - |
? | |
| ATP + NAD+ | - |
Bos taurus | ADP + NADP+ | - |
? | |
| ATP + NAD+ | - |
Pisum sativum | ADP + NADP+ | - |
? | |
| ATP + NAD+ | - |
Azotobacter vinelandii | ADP + NADP+ | - |
? | |
| ATP + NAD+ | - |
Columba sp. | ADP + NADP+ | - |
? | |
| ATP + NAD+ | - |
Homo sapiens | ADP + NADP+ | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | 68 | stable for 5-30 min | Columba sp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 7 | - |
Spinacia oleracea |
| 6.8 | 7 | - |
Nicotiana tabacum |
| 7 | - |
- |
Gallus gallus |
| 7 | - |
- |
Oryctolagus cuniculus |
| 7 | 7.6 | enzyme from liver | Columba sp. |
| 7.2 | 8 | - |
Azotobacter vinelandii |
| 7.2 | 8 | enzyme from heart muscle | Columba sp. |
| 7.4 | 7.5 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Gallus gallus | |
| NAD+ | - |
Cyberlindnera jadinii | |
| NAD+ | - |
Saccharomyces cerevisiae | |
| NAD+ | - |
Bos taurus | |
| NAD+ | - |
Pisum sativum | |
| NAD+ | - |
Azotobacter vinelandii | |
| NAD+ | - |
Columba sp. | |
| NAD+ | - |
Homo sapiens | |
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