Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H-1299 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + thymidine | - |
Homo sapiens | ADP + dTMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thymidine kinase 1 | - |
Homo sapiens |
TK1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | DNA damage causes up-regulation of thymidine kinase 1 in tumor cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of thymidine kinase 1 decreases the efficiency of DNA repair during recovery from DNA damage and generates more cell death | Homo sapiens |
physiological function | thymidine kinase 1 C´contributes to the increase in dTTP pool during recovery from DNA damage and affects the efficiency of DNA repair during recovery for G2/M progression | Homo sapiens |