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Literature summary for 2.7.1.21 extracted from

  • Wang, K.; Mahalingam, G.; Hoover, S.E.; Mont, E.K.; Holland, S.M.; Cohen, J.I.; Straus, S.E.
    Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia (2007), J. Virol., 81, 6817-6826.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine Hsv1-tk mutants are present in multiple ganglia of an immunocompromised patient with a history of chronic Acv(r) skin lesions. Mutations in the thymidine kinase gene of herpes simplex virus type 1 explain in most cases of the virus resistance to acyclvir treatment. Mutants arise independently under drug selection and establish latency in human sensory ganglia alone or together with the wild-type virus Human alphaherpesvirus 1

Organism

Organism UniProt Comment Textmining
Human alphaherpesvirus 1 P03176
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Source Tissue

Source Tissue Comment Organism Textmining