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Literature summary for 2.7.1.207 extracted from

  • Hariharan, P.; Balasubramaniam, D.; Peterkofsky, A.; Kaback, H.R.; Guan, L.
    Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc (2015), Proc. Natl. Acad. Sci. USA, 112, 2407-2412.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C154G inactive Escherichia coli
G46W/G262W inactive Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
phosphotransferase protein IIAGlc protein IIAGlc binding inhibits conformational dynamics of the enzyme and decreases binding affinity for sugar Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Synonyms

Synonyms Comment Organism
lactose permease
-
Escherichia coli
lacY
-
Escherichia coli