Literature summary for 2.7.1.195 extracted from

Sampaio, M.; Chevance, F.; Dippel, R.; Eppler, T.; Schlegel, A.; Boos, W.; Lu, Y.; Rock, C.
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor (2004), J. Biol. Chem., 279, 5537-5548.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.01	-	2-O-alpha-mannosyl-D-glycerate [side 1]	apparent value, at pH 7.6, temperature not specified in the publication	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Escherichia coli	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[protein]-Npi-phospho-L-histidine + 2-O-alpha-mannosyl-D-glycerate [side 1]	Escherichia coli	-	[protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P54745	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[protein]-Npi-phospho-L-histidine + 2-O-alpha-mannosyl-D-glycerate [side 1]	-	Escherichia coli	[protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [side 2]	-	?

Synonyms

Synonyms	Comment	Organism
HrsA	-	Escherichia coli
mngA	-	Escherichia coli

Expression

Organism	Comment	Expression
Escherichia coli	deletion of mngR results in the up-regulation of the gene mngA	up

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Release 2023.1 (January 2023)