Literature summary for 2.7.1.191 extracted from

Plumbridge, J.
Control of the expression of the manXYZ operon in Escherichia coli: Mlc is a negative regulator of the mannose PTS (1998), Mol. Microbiol., 27, 369-380.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli	the enzyme is the major transporter for D-mannose and also transports efficiently D-glucose, 2-deoxyglucose, D-fructose, N-acetylglucosamine, and glucosamine	?	-	?
[protein]-Npi-phospho-L-histidine + D-mannose[side 1]	Escherichia coli	-	[protein]-L-histidine + D-mannose 6-phosphate[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is the major transporter for D-mannose and also transports efficiently D-glucose, 2-deoxyglucose, D-fructose, N-acetylglucosamine, and glucosamine	Escherichia coli	?	-	?
[protein]-Npi-phospho-L-histidine + D-mannose[side 1]	-	Escherichia coli	[protein]-L-histidine + D-mannose 6-phosphate[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
enzyme II	-	Escherichia coli
mannose PTS	-	Escherichia coli
manXYZ	the manXYZ operon (previously ptsM,ptsL) encodes three proteins forming the enzyme II of the so-called mannose PTS which is the major transporter for D-mannose and also transports efficiently D-glucose, 2-deoxyglucose, D-fructose, N-acetylglucosamine, and glucosamine	Escherichia coli

Expression

Organism	Comment	Expression
Escherichia coli	manX gene expression is negatively regulated by NagC and Mlc proteins	down

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Release 2023.1 (January 2023)